What is Vayacog®

    Vayacog® is an orally administered prescription medical food for the clinical dietary management of certain lipid imbalances associated with early memory impairment.

    The unique composition in Vayacog® is Lipicogen™ 310 mg. Lipicogen™ is a proprietary composition containing phosphatidylserine-omega 3, DHA enriched.


Phosphatidylserine (PS) is a kind of lipid that is composed of a negatively charged head group (hydrophilic) and fat-soluble fatty acid tails (lipophilic). PS plays an important role in the normal functioning of cell membranes. Human brain cell membranes are highly enriched with PS compared to other mammalian tissues.

Nerve cells in particular depend on healthy membrane function for normal neuro transmitter metabolism and nerve signal transmission. PS levels in these tissues ensure membrane fluidity and proper structure. Indeed, maintaining brain PS levels has been found to be associated with normal and efficient signal transduction processes, efficient glucose consumption and other biological pathways that are crucial for ensuring normal and healthy cognitive and mental functions (1-4).

Vayacog®, similarly to human brain PS, is characterized by a high level of DHA (docosahexaenoic acid) attached to its backbone. DHA is the major omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) found in the adult brain of many species, including humans. DHA functional sites are exclusively cell membranes, wherein they are structurally and functionally attached via phospholipid molecules. DHA is fundamental for brain functioning. It is required for the development of sensory, perceptual, cognitive and motor neural systems during prenatal and postnatal brain development, and continues to contribute to the highly dynamic, healthy adult brain (5-7).


  • Vayacog® is available by prescription only and its use must be supervised by a physician (for more information on medical foods, see link).
  • Vayacog® recommended dose is one capsule a day or as directed by a physician.


References:

1. McDaniel MA, Maier SF, Einstein GO: Brain-specific nutrients: a memory cure? Nutrition2003;19:957-975. | 2. Mozzi R, Buratta S, Goracci G: Metabolism and functions of phosphatidylserine in mammalian brain. Neurochem Res 2003;28:195-214. | 3. Pepeu G, Pepeu IM, Amaducci L: A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol Res 1996;33:73-80. | 4. Vance JE, Steenbergen R: Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005;44:207-234. | 5. Soderberg, M., et al: Lipid composition in different regions of the brain in Alzheimer’s disease/senile dementia of Alzheimer’s type. J Neurochem, 1992. 59(5): p. 1646-53. | 6. Conquer, J.A., et al: Fatty acid analysis of blood plasma of patients with Alzheimer’s disease, other types of dementia, and cognitive impairment. Lipids, 2000. 35(12): p. 1305-12. | 7. Chang CY, Ke DS, Chen JY: Essential fatty acids and human brain. Acta Neurol Taiwan, 2009.18(4):231-41.